Matthew Cohen wants his startup TRiQ to be the Toyota of marijuana manufacturing. The company, which opened its doors in Ukiah, Cal. in 2013, has a long way to go. But already, TRiQ is partnering with software and manufacturing companies outside the cannabis industry in an attempt to revamp the way marijuana is being produced. “Toyota is one of our idols,” Cohen says. “How they took car manufacturing systems and totally reinvented it — that’s similar to what we are trying to do for cannabis now.”

Meanwhile, up north, just outside of Detroit, Sam Alawieh, CEO and founder of the pharmaceutical company RXNB, has developed closed-door climate bay technology to replicate the exact environment of 50 different strains of marijuana in a controlled and sterile manufacturing environment. Alawieh, whose background is in pharmacology, has 32 patents pending on marijuana-related technologies. “People have been focused on access,” he says. “But the second-wave evolution is about predictability and accountability.”

Read more: Marijuana manufacturing 2.0 | Fortune